Structure of PDB 4c2u Chain A Binding Site BS01

Receptor Information

>4c2u Chain A (length=658) Species: 1299 (Deinococcus radiodurans)

SAGPDLLQALNPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHY
GVHPGEILAVTFTNKAAAEMRERAGHLVPGAGDLWMSTFHSAGVRILRTY
GEHIGLRRGFVIYDDDDQLDIIKEVMGSIPGETQPRVIRGIIDRAKSNLW
TPDDLDRSREPFISGLPRDAAAEAYRRYEVRKKGQNAIDFGDLITETVRL
FKEVPGVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLASRDRNLLVVGDP
DQSIYKFRGADIQNILDFQKDYPDAKVYMLEHNYRSSARVLEAANKLIEN
NTERLDKTLKPVKEAGQPVTFHRATDHRAEGDYVADWLTRLHGEGRAWSE
MAILYRTNAQSRVIEESLRRVQIPARIVGGVGFYDRREIRDILAYARLAL
NPADDVALRRIIGRPRRGIGDTALQKLMEWARTHHTSVLTACANAAEQNI
LDRGAHKATEFAGLMEAMSEAADNYEPAAFLRFVMETSGYLDLLRQEGQE
GQVRLENLEELVSAAEEWSQDEANVGGSIADFLDDAALLSSVDDMRTKAE
NKGAPEDAVTLMTLHNAKGLEFPVVFIVGVEQGLLPSKGAIAEGPSGIEE
ERRLFYVGITRAMERLLMTAAQNRMQFGKTNAAEDSAFLEDIEGLFDTVD
PYGQPIEY

Ligand information

>4c2u Chain X (length=24)

acgacctgcgagcactgctttttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4c2u Structural and Mechanistic Insight Into DNA Unwinding by Deinococcus Radiodurans Uvrd.
• Resolution: 2.55 Å
• Binding residue (original residue number in PDB): F65 F196 Y261 F263 R264 R362 T363 N364 R422 R423 G424 I425 G426 T428 A429 S546 S547 T569 H571 Q632 F633
• Binding residue (residue number reindexed from 1): F62 F190 Y255 F257 R258 R356 T357 N358 R416 R417 G418 I419 G420 T422 A423 S540 S541 T563 H565 Q626 F627

Enzymatic activity

• Catalytic site (original residue number in PDB): K38 T39 D227 E228 Q258 R617
• Catalytic site (residue number reindexed from 1): K35 T36 D221 E222 Q252 R611
• Enzyme Commision number: 5.6.2.4: DNA 3'-5' helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:4c2u, PDBe:4c2u, PDBj:4c2u
• PDBsum: 4c2u
• PubMed: 24143224
• UniProt: Q9RTI9