Structure of PDB 4c2t Chain A Binding Site BS01

Receptor Information
>4c2t Chain A (length=650) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGPDLLQALNPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHYG
VHPGEILAVTFTNKAAAEMRERAGHLVPGAGDLWMSTFHSAGVRILRTYG
EHIGLRRGFVIYDDDDQLDIIKEVMGSIPGIGAETQPRVIRGIIDRAKSN
LWTPDDLDRSREPFISGLPRDAAAEAYRRYEVRKKGQNAIDFGDLITETV
RLFKEVPGVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLASRDRNLLVVG
DPDQSIYKFRGADIQNILDFQKDYPDAKVYMLEHNYRSSARVLEAANKLI
ENNTERLDKTLKPVKEAGQPVTFHRATDHRAEGDYVADWLTRLHGEGRAW
SEMAILYRTNAQSRVIEESLRRVQIPARIVGGVGFYDRREIRDILAYARL
ALNPADDVALRRIIGRPRRGIGDTALQKLMEWARTHHTSVLTACANAAEQ
NILDRGAHKATEFAGLMEAMSEAADNYEPAAFLRFVMETSGYLDLLRQEG
QEGQVRLENLEELVSAAEEWSQDEANVGGSIADFLDDAALLSSDMRTKAE
DAVTLMTLHNAKGLEFPVVFIVGVEQGLLPSKGAIAEGPSGIEEERRLFY
VGITRAMERLLMTAAQNRMQFGKTNAAEDSAFLEDIEGLFDTVDPYGQPI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4c2t Structural and Mechanistic Insight Into DNA Unwinding by Deinococcus Radiodurans Uvrd.
Resolution3.997 Å
Binding residue
(original residue number in PDB)		F65 H93 R142 Y261 F263 R264 R362 T363 R422 G424 G426 T428 R459 L544 S546 T569 H571 N572 F633
Binding residue
(residue number reindexed from 1)		F61 H89 R138 Y257 F259 R260 R358 T359 R418 G420 G422 T424 R455 L540 S542 T557 H559 N560 F621
Binding affinityPDBbind-CN: Kd=0.36uM
Enzymatic activity
Catalytic site (original residue number in PDB) K38 T39 D227 E228 Q258 R617
Catalytic site (residue number reindexed from 1) K34 T35 D223 E224 Q254 R605
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000725 recombinational repair
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005829 cytosol
GO:0033202 DNA helicase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c2t, PDBe:4c2t, PDBj:4c2t
PDBsum4c2t
PubMed24143224
UniProtQ9RTI9

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