Structure of PDB 4c1q Chain A Binding Site BS01

Receptor Information
>4c1q Chain A (length=173) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMSQDDDYLYCEKCQNFFIDSCPNHGPPLFVKDSMVDRGHPNHSVLSLPP
GLRISPSGIPEAGLGVWNEASDLPVGLHFGPYEGQITEDEEAANSGYSWL
ITKGRNCYEYVDGQDESQANWMRYVNCARDDEEQNLVAFQYHRKIFYRTC
RVIRPGCELLVWYGDEYGQELGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4c1q Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of Prdm9.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Y276 A287 G290 S292 W293 Y357 E360 Y361 E364
Binding residue
(residue number reindexed from 1)		Y82 A93 G96 S98 W99 Y163 E166 Y167 E170
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4c1q, PDBe:4c1q, PDBj:4c1q
PDBsum4c1q
PubMed24095733
UniProtQ96EQ9|PRDM9_MOUSE Histone-lysine N-methyltransferase PRDM9 (Gene Name=Prdm9)

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