Structure of PDB 4c07 Chain A Binding Site BS01

Receptor Information
>4c07 Chain A (length=326) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGI
LSIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVEL
PERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAP
ISDQMLEWRLGFWSQVKQHYGVDMSCMESFATRCLMGHSEIVVQDLSGED
VLARPQRFAQLELARAGLEQELEAGVGGRFRCSCYGSAPLHGFAVWFQVT
FPGGKPLVLSTSPLHPATHWKQALLYLNEPVPVEQDTDISGEITLLPSPD
NPRRLRILLRYKVGDHEEKTKDFAME
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4c07 Chain A Residue 1377 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4c07 Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6.
Resolution1.499 Å
Binding residue
(original residue number in PDB)		E158 M160
Binding residue
(residue number reindexed from 1)		E110 M112
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D66 E158 E167 H320
Catalytic site (residue number reindexed from 1) D18 E110 E119 H269
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008469 histone arginine N-methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0042393 histone binding
GO:0044020 histone H4R3 methyltransferase activity
GO:0070611 histone H3R2 methyltransferase activity
GO:0070612 histone H2AR3 methyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0010821 regulation of mitochondrion organization
GO:0018216 peptidyl-arginine methylation
GO:0032259 methylation
GO:0036211 protein modification process
GO:0045892 negative regulation of DNA-templated transcription
GO:0090398 cellular senescence
GO:1901796 regulation of signal transduction by p53 class mediator
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c07, PDBe:4c07, PDBj:4c07
PDBsum4c07
PubMed26094878
UniProtQ6NZB1|ANM6_MOUSE Protein arginine N-methyltransferase 6 (Gene Name=Prmt6)

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