Structure of PDB 4bxf Chain A Binding Site BS01

Receptor Information
>4bxf Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGS
LFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFD
QKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPH
YDDVEVFILQLEGEKHWRLYHPTVPLARECSVEAEERIGRPVHEFMLKPG
DLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDT
AKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSD
MKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPA
QEKMVYIYHSLKNSRETHMMGNEFHGLRFPLSHLDALKQIWNSPAISVKD
LKLTTDEEKESLVLSLWTECLIQVV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4bxf Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		Q136 H138 Q139 L161 N165 Y167 H179 D181 V183 C209 T255 S257 Q260 D333 H337 M405 M406 G407
Binding residue
(residue number reindexed from 1)		Q107 H109 Q110 L132 N136 Y138 H150 D152 V154 C180 T226 S228 Q231 D304 H308 M369 M370 G371
Enzymatic activity
Enzyme Commision number 1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0032452 histone demethylase activity
GO:0032453 histone H3K4 demethylase activity
GO:0036139 peptidyl-histidine dioxygenase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0051864 histone H3K36 demethylase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0042254 ribosome biogenesis
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4bxf, PDBe:4bxf, PDBj:4bxf
PDBsum4bxf
PubMed24814345
UniProtQ8IUF8|RIOX2_HUMAN Ribosomal oxygenase 2 (Gene Name=RIOX2)

[Back to BioLiP]