Structure of PDB 4bwz Chain A Binding Site BS01

Receptor Information

>4bwz Chain A (length=384) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GAEHLLEIFYLLLAAQVCAFIFKRLNQPVVIGEVLAGVLVGPALLGLVHE
GEILEFLAELGAVFLLFMVGLETRLKDILAVGKEAFLVAVLGVALPFLGG
YLYGLEIGFETLPALFLGTALVATSVGITARVLQELGVLSRPYSRIILGA
AVIDDVLGLIVLACVNGVAETGQVEVGAITRLIVLSVVFVGLAVFLSTLI
ARLPLERLPVGSPLGFALALGVGMAALAASIGLAPIVGAFLGGMLLSEVR
EKYRLEEPIFAIESFLAPIFFAMVGVRLELSALASPVVLVAGTVVTVIAI
LGKVLGGFLGALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGAVNEEE
YAIVLFMVVFTTLFAPFALKPLIAWTERERAAKE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4bwz Chain A Residue 1387 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4bwz A two-domain elevator mechanism for sodium/proton antiport.
Resolution	2.984 Å
Binding residue (original residue number in PDB)	E5 E9 H51
Binding residue (residue number reindexed from 1)	E3 E7 H49
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0015297	antiporter activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006812	monoatomic cation transport
GO:0055085	transmembrane transport
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4bwz, PDBe:4bwz, PDBj:4bwz
PDBsum	4bwz
PubMed	23995679
UniProt	Q72IM4

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