Structure of PDB 4bup Chain A Binding Site BS01

Receptor Information
>4bup Chain A (length=232) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTRQEELKEVIERF
KKDEHLEKAFKCLTSLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNR
YSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSV
MYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEE
ISCYYGDGFFGENNEFCECYTCERRGTGAFKS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4bup Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4bup A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Resolution2.166 Å
Binding residue
(original residue number in PDB)		C267 C311 C313 C316
Binding residue
(residue number reindexed from 1)		C173 C217 C219 C222
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4bup, PDBe:4bup, PDBj:4bup
PDBsum4bup
PubMed24049080
UniProtQ3U8K7|KMT5B_MOUSE Histone-lysine N-methyltransferase KMT5B (Gene Name=Kmt5b)

[Back to BioLiP]