Structure of PDB 4bp9 Chain A Binding Site BS01

Receptor Information
>4bp9 Chain A (length=710) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RGPIAAHRPHEVVFGKVEGEDRGANPMDPPRRRVDPLFWLRDDNRADPEV
LAHLHLEKDYYEKRAVDIKDLAETIYQEHISHIEETDMSAPYVYDRFLYY
TRDVKGLSYKLHCRVPAGKTPGEGEDEEIVLDENKLAEGKSFCVVGCVAP
APPEHALVAYSVDYCGDEVYSIRFVRDVVADKVEGTNGSVVWGPNAECFF
YITKDASKRDNKVWRHIIGQPQSEDVCLYTDDDPLFSVGVGRSGDGKTLI
ICSMSSETSESHLLDLRKGVKHNTLEMVRPREKGVRYTVEMHGTDTLIVL
TNKDKCVNGKVVLTKRSAPTDWGTVLIPHDDKVTIDDVAVFAKFAVLSGR
RDGLTRVWTVRLGPDNLFSSATLKELHFDEPVFTAHVVCSQMKTYDASLL
RLRYSSMTTPTVWYDEDVLSGERKVVKARKVGGGFESKNYVCRRELATAP
DGTKVPISLVYDTSIDLKKPNPTMLYGYGSYGICIEPEFNSRFLPYVDRG
MIYAIAHVRGGGEMGRTWYEVGGKYLTKRNTFMDFIACAEHLISSGLTTP
AQLSCEGRSAGGLLVGAVLNMRPDLFHVALAGVPFVDVMTTMCDPSIPLT
TGEWEEWGNPNEYKFFDYMNSYSPIDNVRAQDYPHLMIQAGLHDPRVAYW
EPAKWASKLRELKTDSNEVLLKMDLESGHFSASDRYKYLRENAIQQAFVL
KHLNVRQLLR
Ligand information
Receptor-Ligand Complex Structure
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PDB4bp9 Crystal Structures of Trypanosoma Brucei Oligopeptidase B Broaden the Paradigm of Catalytic Regulation in Prolyl Oligopeptidase Family Enzymes.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		N191 K208 D214 Y485 S563 A564 F589 E607 R650 V651
Binding residue
(residue number reindexed from 1)		N187 K204 D210 Y481 S559 A560 F585 E603 R646 V647
Enzymatic activity
Catalytic site (original residue number in PDB) Y482 S563 D648 H683
Catalytic site (residue number reindexed from 1) Y478 S559 D644 H679
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bp9, PDBe:4bp9, PDBj:4bp9
PDBsum4bp9
PubMed24265767
UniProtO76728

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