Structure of PDB 4b9n Chain A Binding Site BS01

Receptor Information

>4b9n Chain A (length=581) Species: 1422 (Geobacillus stearothermophilus)

TAKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFF
LRPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLL
LAAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAE
HLVRKAAAIWALERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKV
DTKRLEQMGEELAEQLRTVEQRIYELAGQEFNINSPKQLGVILFEKLQLP
VLKKSKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVV
RPDTKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSES
DWLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSED
EVTPNMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPG
VKRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTP
IQGSAADIIKKAMIDLNARLKEERLQARLLLQVHDELILEAPKEEMERLC
RLVPEVMEQAVTLRVPLKVDYHYGSTWYDAK

Ligand information

>4b9n Chain B (length=10)

tgactctttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4b9n Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): K551 T552 T556 A558 R578 K582 Y587 Q624 N625 I626 P627 I628 R629 Y714 H829 D830
• Binding residue (residue number reindexed from 1): K256 T257 T261 A263 R283 K287 Y292 Q329 N330 I331 P332 I333 R334 Y419 H534 D535

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0004518 nuclease activity
• GO:0008408 3'-5' exonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006302 double-strand break repair
• GO:0006974 DNA damage response
• GO:0071897 DNA biosynthetic process

External links

• PDB: RCSB:4b9n, PDBe:4b9n, PDBj:4b9n
• PDBsum: 4b9n
• PubMed: 23685671
• UniProt: E1C9K5