BioLiP

Receptor Information

>4b2z Chain A (length=399) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTN
QLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEY
FTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRF
LGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIE
LGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGKW
NDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKV
TDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGED
LDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQ

Ligand ID

P5S

InChI

InChI=1S/C42H82NO10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49)/t38-,39+/m1/s1

InChIKey

TZCPCKNHXULUIY-RGULYWFUSA-N

SMILES

Software	SMILES
CACTVS 3.370	CCCCCCCCCCCCCCCCCC(=O)OC[CH](CO[P](O)(=O)OC[CH](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC
CACTVS 3.370	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P](O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC
ACDLabs 12.01	O=C(OC(COP(=O)(OCC(C(=O)O)N)O)COC(=O)CCCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCCC
OpenEye OEToolkits 1.7.6	CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
OpenEye OEToolkits 1.7.6	CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OC[C@@H](C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC

Formula

C42 H82 N O10 P

Name

O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine;
phosphatidyl serine

PDB chain

4b2z Chain A Residue 1436 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4b2z Interactome Map Uncovers Phosphatidylserine Transport by Oxysterol-Binding Proteins
Resolution	1.95 Å
Binding residue (original residue number in PDB)	L64 I67 L69 I73 M79 R82 Q86 L87 W112 Y113 K125 K126 P127 N129 S183 A191 A192 M194 V222 M232 I234
Binding residue (residue number reindexed from 1)	L29 I32 L34 I38 M44 R47 Q51 L52 W77 Y78 K90 K91 P92 N94 S148 A156 A157 M159 V187 M197 I199
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0001786	phosphatidylserine binding
GO:0005548	phospholipid transporter activity
GO:0008289	lipid binding
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032934	sterol binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0070300	phosphatidic acid binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
GO:0120015	sterol transfer activity

	Biological Process
GO:0006869	lipid transport
GO:0006887	exocytosis
GO:0006897	endocytosis
GO:0015914	phospholipid transport
GO:0015918	sterol transport
GO:0016125	sterol metabolic process
GO:0030011	maintenance of cell polarity
GO:0034727	piecemeal microautophagy of the nucleus
GO:0055092	sterol homeostasis

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032541	cortical endoplasmic reticulum

PDB	RCSB:4b2z, PDBe:4b2z, PDBj:4b2z
PDBsum	4b2z
PubMed	23934110
UniProt	Q02201\|OSH6_YEAST Oxysterol-binding protein homolog 6 (Gene Name=OSH6)

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Structure of PDB 4b2z Chain A Binding Site BS01