Structure of PDB 4b18 Chain A Binding Site BS01

Receptor Information
>4b18 Chain A (length=427) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVV
ARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELL
SSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTM
TRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWAL
SYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDD
IQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVID
ANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPL
CDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGL
DKIEFLQSHENQEIYQKAFDLIEHYFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4b18 Akt-Mediated Phosphorylation Increases the Binding Affinity of Htert for Importin Alpha to Promote Nuclear Translocation.
Resolution2.52 Å
Binding residue
(original residue number in PDB)		E113 W149 N153 A155 G157 T162 Q188 W191 N195 G198 D199 W234 R241 W276 G284 R318 T325 K356 E357 R395 E399 W402
Binding residue
(residue number reindexed from 1)		E35 W71 N75 A77 G79 T84 Q110 W113 N117 G120 D121 W156 R163 W198 G206 R240 T247 K278 E279 R317 E321 W324
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4b18, PDBe:4b18, PDBj:4b18
PDBsum4b18
PubMed25999477
UniProtP52294|IMA5_HUMAN Importin subunit alpha-5 (Gene Name=KPNA1)

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