Structure of PDB 4ay2 Chain A Binding Site BS01

Receptor Information
>4ay2 Chain A (length=628) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQNKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVI
ATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRI
CKDLENLSQIQNREFGTQKYEQWIVTVQKACMVEESRICKALFLYTSHLR
KYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQE
LESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNW
IEGNPKLSFLKPGILGDHNILIATSVADEAQCNLVILYEYVSKCFLLTSN
AGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQ
EKPKPVPDKENKKLLCRKCKALACYTADVRVIEDCHYTVLGDAFKECFVS
RPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVV
EDIATGVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>4ay2 Chain C (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcgcggcuucggccgcgcc
<<<<<<<<....>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ay2 Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor Rig-I.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q299 I300 G326 T347 Q349 K379 Q380 H381 I499 N501 Q511 C829 H830 F853 K858 K861 I875 K888 S906
Binding residue
(residue number reindexed from 1)		Q60 I61 G87 T108 Q110 K140 Q141 H142 I260 N262 Q272 C535 H536 F559 K564 K567 I581 K594 S612
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4ay2, PDBe:4ay2, PDBj:4ay2
PDBsum4ay2
PubMed23022350
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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