Structure of PDB 4axv Chain A Binding Site BS01

Receptor Information
>4axv Chain A (length=241) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLFQGPAMSLIPRTERAAFLITPTSYGKSVLGAPLLYFPAQVESNSRGLI
LAGTHGDETASIAGLSCALRSLPAECLKHDVILSMNPDANQLGTRANANQ
VDLNRAFPTQNWTEHGTVYRWSSHTPVRDVKVKTGDKEQLEPEVDALISL
IELRRPKFVVSFHEPLAFVDDPAHSDLAKWLGKQFNLPIVDDVDYETPGS
FGTWCNERQLPCITVELPPISADLTIEKHLDAFIALLQHDP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4axv Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4axv Mpaa is a Murein-Tripeptide-Specific Zinc Carboxypeptidase that Functions as Part of a Catabolic Pathway for Peptidoglycan Derived Peptides in Gamma-Proteobacteria.
Resolution2.17 Å
Binding residue
(original residue number in PDB)		H48 E51 H156
Binding residue
(residue number reindexed from 1)		H55 E58 H163
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.17.-
Gene Ontology
Molecular Function
GO:0004040 amidase activity
GO:0004180 carboxypeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
GO:0061473 murein tripeptide carboxypeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4axv, PDBe:4axv, PDBj:4axv
PDBsum4axv
PubMed22970852
UniProtA7N805|MPAA_VIBC1 Murein peptide amidase A (Gene Name=mpaA)

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