Structure of PDB 4awb Chain A Binding Site BS01

Receptor Information

>4awb Chain A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIA
YSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVK
GIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYK
HKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKR
STYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTQTSHVMQYGNKTI
STMKVMQFQGM

Ligand information

>4awb Chain I (length=3) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4awb Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation
Resolution	2.7 Å
Binding residue (original residue number in PDB)	S216 Y217 A218 Y228
Binding residue (residue number reindexed from 1)	S191 Y192 A193 Y203

Enzymatic activity

Enzyme Commision number

3.4.22.34: legumain.

Gene Ontology

	Molecular Function
GO:0008233	peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:4awb, PDBe:4awb, PDBj:4awb
PDBsum	4awb
PubMed	23776206
UniProt	Q99538\|LGMN_HUMAN Legumain (Gene Name=LGMN)

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