Structure of PDB 4au7 Chain A Binding Site BS01

Receptor Information
>4au7 Chain A (length=243) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPTLRRQHHLRSALE
AFLRQRDLEAAFRALTLGGWMAHYFQSRAPRQEAALKTHIFCYLRAFLPE
SGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREEDEDLL
RAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPSDGNTACVKV
LRDIEPGDEVTCFYGEGFFGEKNEHCECYTCERKGEGAFRLQP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4au7 A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		D159 F160 S161 I162 M163 Y164 T166 R167 F191 P193 Y217 F221
Binding residue
(residue number reindexed from 1)		D156 F157 S158 I159 M160 Y161 T163 R164 F188 P190 Y214 F218
Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4au7, PDBe:4au7, PDBj:4au7
PDBsum4au7
PubMed24049080
UniProtQ6Q783|KMT5C_MOUSE Histone-lysine N-methyltransferase KMT5C (Gene Name=Kmt5c)

[Back to BioLiP]