Structure of PDB 4arf Chain A Binding Site BS01

Receptor Information
>4arf Chain A (length=380) Species: 1498 (Hathewaya histolytica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YCPKTYTFDDGKVIIKAGARVEEEKVKRLYWASKEVNSQFFRVYGIDKPL
EEGNPDDILTMVIYNSPEEYKLNSVLYGYDTNNGGMYIEPEGTFFTYERE
AQESTYTLEELFRHEYTHYLQGRYAVPGQWGRTKLYDNDRLTWYEEGGAE
LFAGSTRTSGILPRKSIVSNIHNTTRNNRYKLSDTVHSKYGASFEFYNYA
CMFMDYMYNKDMGILNKLNDLAKNNDVDGYDNYIRDLSSNHALNDKYQDH
MQERIDNYENLTVPFVADDYLVRHAYKNPNEIYSEISEVAKLKDAKSEVK
KSQYFSTFTLRGSYTGGVSKGKLEDQKAMNKFIDDSLKKLDTYSWSGYKT
LTAYFTNYKVDSSNKVTYDVVFHGYLPNEG
Ligand information
Receptor-Ligand Complex Structure
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PDB4arf Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T.
Resolution1.77 Å
Binding residue
(original residue number in PDB)		N424 G425 G426 S445 Y447 L452 H455 E456 H459 E487 Y531 F535 Y538
Binding residue
(residue number reindexed from 1)		N83 G84 G85 S104 Y106 L111 H114 E115 H118 E146 Y190 F194 Y197
Enzymatic activity
Enzyme Commision number 3.4.24.3: microbial collagenase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4arf, PDBe:4arf, PDBj:4arf
PDBsum4arf
PubMed23703618
UniProtQ46085|COLH_HATHI Collagenase ColH (Gene Name=colH)

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