Structure of PDB 4af1 Chain A Binding Site BS01

Receptor Information
>4af1 Chain A (length=410) Species: 478009 (Halobacterium salinarum R1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPSEDRRKYEFRKVIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEH
SEASNIKSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGAVDSGGG
RTDMVTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRR
ESNVGWLKGKRVQPVKSAESLVPGKQRKGGQSAQRFARLRLEAIDNFYQE
VAGMADDLFVPKRHEIDGILVGGPSPTKDEFLDGDYLHHELQDKVLGKFD
VSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGGKLATYGFE
QTRRNLIMGSVDRLLVSEDLREDVVIYECPNDHEEYETIDRRNTSPEHTC
SDCGEEATEVDREDAIDHLMSIADQRGTETHFISTDFEKGEQLLTAFGGY
AGILRYSTGV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4af1 Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4af1 Archeal Release Factor Arf1 Contains a Metal Binding Domain
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C335 H339 C356 C359
Binding residue
(residue number reindexed from 1)		C329 H333 C350 C353
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0006412 translation
GO:0006415 translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0018444 translation release factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4af1, PDBe:4af1, PDBj:4af1
PDBsum4af1
PubMed
UniProtB0R748|RF1_HALS3 Peptide chain release factor subunit 1 (Gene Name=prf1)

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