Structure of PDB 4a1t Chain A Binding Site BS01

Receptor Information

>4a1t Chain A (length=193)

GSVVIVGRIILSPITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTA
TQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPP
GARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSS
GGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRGS

Ligand information

>4a1t Chain C (length=17) Species: 32630 (synthetic construct)

GRLVYLLDGPGYDPIHC

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4a1t High Affinity Peptide Inhibitors of the Hepatitis C Virus Ns3-4A Protease Refractory to Common Resistant Mutants.
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): V-9 S7 Q9 L13 S37 A39 Q41 S42 H57 R109 V132 L135 K136 G137 S139 F154 R155 A156 A157 V158 C159
• Binding residue (residue number reindexed from 1): V6 S18 Q20 L24 S48 A50 Q52 S53 H68 R120 V143 L146 K147 G148 S150 F165 R166 A167 A168 V169 C170

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D81 G137 S139
• Catalytic site (residue number reindexed from 1): H68 D92 G148 S150
• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.21.98: hepacivirin.
  3.4.22.-
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019087 transformation of host cell by virus

External links

• PDB: RCSB:4a1t, PDBe:4a1t, PDBj:4a1t
• PDBsum: 4a1t
• PubMed: 22965230
• UniProt: P26662|POLG_HCVJA Genome polyprotein