Structure of PDB 4a15 Chain A Binding Site BS01

Receptor Information
>4a15 Chain A (length=596) Species: 2303 (Thermoplasma acidophilum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQYQVEAIDFLRSSLQKSYGVALESPTGSGKTIMALKSALQYSSERKLKV
LYLVRTNSQEEQVIKELRSLSSTMKIRAIPMQGRVNMCILYRMVDDLHEI
NAESLAKFCNMKKREVMAGNEAACPYFNFKIRSDETKRFLFDELPTAEEF
YDYGERNNVCPYESMKAALPDADIVIAPYAYFLNRSVAEKFLSHWGVSRN
QIVIILDEAHNLPDIGRSIGSFRISVESLNRADREAQAYGDPELSQKIHV
SDLIEMIRSALQSMVSERCGKGDVRIRFQEFMEYMRIMNKRSEREIRSLL
NYLYLFGEYVENEKEKVGKVPFSYCSSVASRIIAFSDQDEEKYAAILSPE
DGGYMQAACLDPSGILEVLKESKTIHMSGTLDPFDFYSDITGFEIPFKKI
GEIFPPENRYIAYYDGVDEKELDRMATVIEDIILKVKKNTIVYFPSYSLM
DRVENRVSFEHMKEYRGIDQKELYSMLKKFRRDHGTIFAVSGGRLNELEM
IILAGLPFPRPDAINRSLFDYYERKYGKGWEYSVVYPTAIKIRQEIGRLI
RSAEDTGACVILDKRAGQFRKFIPDMKKTSDPASDIYNFFISAQAR
Ligand information
Receptor-Ligand Complex Structure
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PDB4a15 Functional and Structural Studies of the Nucleotide Excision Repair Helicase Xpd Suggest a Polarity for DNA Translocation.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		F527 P528 P530 W549 R584
Binding residue
(residue number reindexed from 1)		F508 P509 P511 W530 R565
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:4a15, PDBe:4a15, PDBj:4a15
PDBsum4a15
PubMed22081108
UniProtQ9HM14|XPD_THEAC ATP-dependent DNA helicase XPD (Gene Name=Ta0057)

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