Structure of PDB 4a0i Chain A Binding Site BS01

Receptor Information
>4a0i Chain A (length=136) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDL
AQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKL
DRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4a0i Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex.
Resolution2.605 Å
Binding residue
(original residue number in PDB)		E51 K62 E63 L64 E65 W67 E76 H80
Binding residue
(residue number reindexed from 1)		E47 K58 E59 L60 E61 W63 E72 H76
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019899 enzyme binding
GO:0031267 small GTPase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007605 sensory perception of sound
GO:0008284 positive regulation of cell population proliferation
GO:0010466 negative regulation of peptidase activity
GO:0031503 protein-containing complex localization
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0051256 mitotic spindle midzone assembly
GO:0051301 cell division
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090307 mitotic spindle assembly
GO:1901970 positive regulation of mitotic sister chromatid separation
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903490 positive regulation of mitotic cytokinesis
Cellular Component
GO:0000228 nuclear chromosome
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:1990713 survivin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a0i, PDBe:4a0i, PDBj:4a0i
PDBsum4a0i
PubMed22032967
UniProtO15392|BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 (Gene Name=BIRC5)

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