Structure of PDB 3zvn Chain A Binding Site BS01

Receptor Information
>3zvn Chain A (length=377) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WESLKKLLVFTASGVKPQGKVAAFNLDGTLITTRSGKVFPTSPSDWRILY
PEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLGVP
FQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRLAN
WAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTI
SSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNR
DTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCR
CFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFL
EILEIPFRLQEHLDPALQRLYRQFSEG
Ligand information
Receptor-Ligand Complex Structure
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PDB3zvn The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		R395 D396 W401 T423 R432 H470 V477
Binding residue
(residue number reindexed from 1)		R250 D251 W256 T278 R287 H325 V332
Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3zvn, PDBe:3zvn, PDBj:3zvn
PDBsum3zvn
PubMed22055185
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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