Structure of PDB 3zvm Chain A Binding Site BS01

Receptor Information
>3zvm Chain A (length=380) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLGWESLKKLLVFTASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWR
ILYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKL
GVPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGR
LANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDP
RTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVH
VNRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGV
PCRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAE
GFLEILEIPFRLQEHLDPALQRLYRQFSEG
Ligand information
Receptor-Ligand Complex Structure
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PDB3zvm The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
Resolution1.997 Å
Binding residue
(original residue number in PDB)		D172 F184 N217 M219 G220 R258 F305
Binding residue
(residue number reindexed from 1)		D30 F42 N75 M77 G78 R116 F163
Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3zvm, PDBe:3zvm, PDBj:3zvm
PDBsum3zvm
PubMed22055185
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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