Structure of PDB 3zrp Chain A Binding Site BS01

Receptor Information

>3zrp Chain A (length=377) Species: 273057 (Saccharolobus solfataricus P2)

LHVGPTTIKEDVLVAGLENNVGFTSKEFVEALAYSLKGLRYVMGASKNYQ
PLIIPGGGTSAMESVTSLLKPNDKILVVSNGVFGDRWEQIFKRYPVNVKV
LRPSPGDYVKPGEVEEEVRKSEYKLVALTHVETSTGVREPVKDVINKIRK
YVELIVVDGVSSVGAEEVKAEEWNVDVYLTASQKALGSAAGLGLLLLSPK
ALSILDSQNSIAGYYLDLRNWLPVMRGAEEGKAAYFATPPVHVILQLAEA
FRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIVARRPESYSNTVTGVI
LKVADPQKVLAGTVNEGVEFAPGVHPAFKYFRIGHMGWVTPNDAIIAISV
IERTLRKLGEPIRFGEGVKAVEEVLFS

Ligand information

• Ligand ID: PLP
• InChI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
• InChIKey: NGVDGCNFYWLIFO-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
  OpenEye OEToolkits 1.5.0: Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
  ACDLabs 10.04: O=P(O)(O)OCc1cnc(c(O)c1C=O)C
• Formula: C8 H10 N O6 P
• Name: PYRIDOXAL-5'-PHOSPHATE;
  VITAMIN B6 Phosphate
• ChEMBL: CHEMBL82202
• DrugBank: DB00114
• ZINC: ZINC000001532514
• PDB chain: 3zrp Chain A Residue 1189

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3zrp Crystal Structure and Substrate Specificity of the Thermophilic Serine:Pyruvate Aminotransferase from Sulfolobus Solfataricus
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): G62 G63 T64 F88 T138 D163 V165 K189
• Binding residue (residue number reindexed from 1): G57 G58 T59 F83 T133 D158 V160 K184
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.6.1.51: serine--pyruvate transaminase.

Gene Ontology

Molecular Function

• GO:0004760 L-serine-pyruvate transaminase activity
• GO:0008453 alanine-glyoxylate transaminase activity
• GO:0008483 transaminase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0019265 glycine biosynthetic process, by transamination of glyoxylate

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:3zrp, PDBe:3zrp, PDBj:3zrp
• PDBsum: 3zrp
• PubMed: 22751661
• UniProt: Q97VM5