Structure of PDB 3zmq Chain A Binding Site BS01

Receptor Information
>3zmq Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSR
IKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRG
VVMLNRYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQE
TREILHFHYTTWPDFGVPPASFLNFLFKVRESGSLSPEHGPVVVHSSAGI
GRSGTFCLADTCLLLMDKRPSSVDIKKVLLEMRKFRMGLIQTADQLRFSY
LAVIEGAK
Ligand information
Receptor-Ligand Complex Structure
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PDB3zmq Development of Accessible Peptidic Tool Compounds to Study the Phosphatase Ptp1B in Intact Cells.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Y46 R47 D48 D181 F182 S215 S216 A217 G220 R221 Q262
Binding residue
(residue number reindexed from 1)		Y40 R41 D42 D164 F165 S196 S197 A198 G201 R202 Q241
Enzymatic activity
Catalytic site (original residue number in PDB) D181 S215 R221 S222 Q262
Catalytic site (residue number reindexed from 1) D164 S196 R202 S203 Q241
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3zmq, PDBe:3zmq, PDBj:3zmq
PDBsum3zmq
PubMed24387659
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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