Structure of PDB 3zmp Chain A Binding Site BS01

Receptor Information
>3zmp Chain A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPF
DHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQ
KSRGVVMLNRVMLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVR
QLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSP
EHGPVVVHSSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKF
RMGLIQTADQLRFSYLAVIEGAKFIM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3zmp Development of Accessible Peptidic Tool Compounds to Study the Phosphatase Ptp1B in Intact Cells.
Resolution2.619 Å
Binding residue
(original residue number in PDB)		Y46 D48 F182 S215 S216 A217 I219 G220 R221 Q262
Binding residue
(residue number reindexed from 1)		Y44 D46 F176 S209 S210 A211 I213 G214 R215 Q256
Enzymatic activity
Catalytic site (original residue number in PDB) D181 S215 R221 S222 Q262
Catalytic site (residue number reindexed from 1) D175 S209 R215 S216 Q256
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3zmp, PDBe:3zmp, PDBj:3zmp
PDBsum3zmp
PubMed24387659
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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