Structure of PDB 3zjv Chain A Binding Site BS01

Receptor Information
>3zjv Chain A (length=813) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHM
GHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPW
TYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVY
KKTSAVEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGV
EITFNVNDYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAA
FIDECRNTMEKKGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVP
GHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEKGVLFNSGEFNG
LDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLED
GTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNGMPALRETDT
FDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLL
YFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPV
DAIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGA
DTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTAKGDVAAL
NVDALTENQKALRRDVHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKA
PTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGDIDNAPWPV
ADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYV
IYVPGKLLNLVVG
Ligand information
>3zjv Chain B (length=85) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggaugguggaaucgguagacacaagggauuaaaucccucggcguuc
gcgcugugcggguucaagucccgcuccggguacca
<<<<<<<..<<<...........>>>.<<<<<<...>>>>>>.<<<<<..
>>>>>..<<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3zjv Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		S227 Y246 T247 T248 R249 M298 E299 K300 F325 V326 L327 Y330 V335 M336 D342 R344 D345 R416 R418 K598 R600 F648 E657 S661 R668 R672 K711 R719 N723 A727 M730 E731 N734 K813 I848 V850
Binding residue
(residue number reindexed from 1)		S197 Y216 T217 T218 R219 M259 E260 K261 F286 V287 L288 Y291 V296 M297 D303 R305 D306 R377 R379 K559 R561 F609 E618 S622 R629 R633 K672 R680 N684 A688 M691 E692 N695 K774 I801 V803
Enzymatic activity
Catalytic site (original residue number in PDB) L41 H49 H52 D80 F493 H533 F543 K619 K622
Catalytic site (residue number reindexed from 1) L41 H49 H52 D80 F454 H494 F504 K580 K583
Enzyme Commision number 6.1.1.4: leucine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zjv, PDBe:3zjv, PDBj:3zjv
PDBsum3zjv
PubMed23295920
UniProtP07813|SYL_ECOLI Leucine--tRNA ligase (Gene Name=leuS)

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