Structure of PDB 3zin Chain A Binding Site BS01

Receptor Information

>3zin Chain A (length=426) Species: 10090 (Mus musculus)

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

Ligand information

>3zin Chain B (length=13) Species: 10090 (Mus musculus)

SRGQKRSFSKAFG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3zin Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-Alpha
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): R315 V321 D325 K353 E354 W357 N361 A364 G365 E396 W399 N403 S406
• Binding residue (residue number reindexed from 1): R244 V250 D254 K282 E283 W286 N290 A293 G294 E325 W328 N332 S335

Enzymatic activity

• Catalytic site (original residue number in PDB): T151 A163 N361 R366 Q367
• Catalytic site (residue number reindexed from 1): T80 A92 N290 R295 Q296

Gene Ontology

Molecular Function

• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3zin, PDBe:3zin, PDBj:3zin
• PDBsum: 3zin
• PubMed: 23910026
• UniProt: P52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)