Structure of PDB 3zfd Chain A Binding Site BS01

Receptor Information
>3zfd Chain A (length=340) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVKGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGNDKSFTYDF
VFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYT
AEQEHDSAIGVIPRVIQLLFKEINKKSDFEFTLKVSYLEIYNEEILDLLC
STQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTVASTAMNS
QSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRL
REGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHT
LMIACVSPADSNLEETLNTLRYADRARKIKNKPIINHHHH
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3zfd Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3zfd Structural Basis for the ATP-Induced Isomerization of Kinesin.
Resolution1.71 Å
Binding residue
(original residue number in PDB)		T95 S211
Binding residue
(residue number reindexed from 1)		T92 S203
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.4.4: Transferred entry: 5.6.1.3.
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3zfd, PDBe:3zfd, PDBj:3zfd
PDBsum3zfd
PubMed23500491
UniProtP33174|KIF4_MOUSE Chromosome-associated kinesin KIF4 (Gene Name=Kif4)

[Back to BioLiP]