Structure of PDB 3wy9 Chain A Binding Site BS01

Receptor Information

>3wy9 Chain A (length=416) Species: 70601 (Pyrococcus horikoshii OT3)

KPHVNIVFIGHVDHGKSTTIGRLLYDTGNIPETIIKKFESFKFAWVMDRL
KEERERGITIDVAHTKFETPHRYITIIDAPGHRDFVKNMITGASQADAAV
LVVAATDGVMPQTKEHAFLARTLGIKHIIVTINKMDMVNYDQKVFEKVKA
QVEKLLKTLGYKDFPVIPTSAWNGDNVVKKSDKMPWYNGPTLIEALDQIP
EPEKPIDKPLRIPIQDVYSIKGVGTVPVGRVETGKLKVGDVVIFEPASTI
FHKPIQGEVKSIEMHHEPLQEALPGDNIGFNVRGVSKNDIKRGDVAGHTD
KPPTVVRTKDTFKAQIIVLNHPTAITVGYSPVLHAHTAQIPVRFEQILAK
VDPRTGNIVEENPQFIKTGDSAIVVLRPMKPVVLEPVKEIPQLGRFAIRD
MGMTIAAGMVISIQKG

Ligand information

>3wy9 Chain C (length=26) Species: 70601 (Pyrococcus horikoshii OT3)

EKKEEEEKEEEVSEEEALAGLSALFG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3wy9 Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1 alpha.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): K125 F129 K324 I384 S423
• Binding residue (residue number reindexed from 1): K114 F118 K313 I373 S412

Enzymatic activity

• Catalytic site (original residue number in PDB): D17 K20 S21 T70 H93
• Catalytic site (residue number reindexed from 1): D13 K16 S17 T59 H82

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3wy9, PDBe:3wy9, PDBj:3wy9
• PDBsum: 3wy9
• PubMed: 25428348
• UniProt: O59153|EF1A_PYRHO Elongation factor 1-alpha (Gene Name=tuf)