Structure of PDB 3wuh Chain A Binding Site BS01

Receptor Information
>3wuh Chain A (length=344) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGYKVLAIETSCDDTCVSVLDRFSKSAAPNVLANLKDTLDKAHIHHQARI
GPLTERALIESNAREGIDLICVTRGPGMPGSLSGGLDFAKGLAVAWNKPL
IGVHHMLGHLLIPRMGTNGKVPQFPFVSLLVSGGHTTFVLSRAIDDHEIL
CDTIDIAVGDSLDKCGRELGFKGTMIAREMEKFINQDINDQDFALKLEMP
RNMLSFSFSAFITALRTNLTKLGKTPEREIRSIAYQVQESVFDHIINKLK
HVLKSQPEKFKNVREFVCSGGVSSNQRLRTKLETELFNFYYPPMDLCSDN
SIMIGWAGIEIWESLRLVSDLDICPIRQWPLNDLLSVDGWRTDQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3wuh Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3wuh Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP
Resolution2.937 Å
Binding residue
(original residue number in PDB)		H145 H149 H175 D361
Binding residue
(residue number reindexed from 1)		H105 H109 H135 D299
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0008252 nucleotidase activity
GO:0008270 zinc ion binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
GO:0072670 mitochondrial tRNA threonylcarbamoyladenosine modification
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wuh, PDBe:3wuh, PDBj:3wuh
PDBsum3wuh
PubMed25084372
UniProtP43122|QRI7_YEAST tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (Gene Name=QRI7)

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