Structure of PDB 3wsz Chain A Binding Site BS01

Receptor Information
>3wsz Chain A (length=561) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLPKSSDVYVSYDY
GKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITF
DFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTW
IMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQE
VILEEVRDFQLRDKYMFATKVVHLLGSLWVSFGRKPMRAAQFVTRHPINE
YYIADASEDQVFVCVSHSNNRTNLYISEKFSLSLENVLYYSPGGAGSDTL
VRYFANEPFADFHRVEGLQGVYIATLINGNMRSVITFDKGGTWEFLQAPA
FTGKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSV
GKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNE
LKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSW
LILQVNATDALGVPCTENDYKLWSPSDERGNECKTVFKRRTPHATCFNGE
DFDRPVVVSNC
Ligand information
Receptor-Ligand Complex Structure
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PDB3wsz Structural basis for amyloidogenic peptide recognition by sorLA.
Resolution3.201 Å
Binding residue
(original residue number in PDB)		N103 Q104 M105 V106 V107 R490 Y584 H608
Binding residue
(residue number reindexed from 1)		N16 Q17 M18 V19 V20 R380 Y474 H498
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:3wsz, PDBe:3wsz, PDBj:3wsz
PDBsum3wsz
PubMed25643321
UniProtQ92673|SORL_HUMAN Sortilin-related receptor (Gene Name=SORL1)

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