Structure of PDB 3wqy Chain A Binding Site BS01

Receptor Information
>3wqy Chain A (length=905) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLDEEYLDITFLTENGFVRKRCPKCGKHFWTADPEREICGDPPCESYSFI
GNPVFKKPFELDEMREYYLNFFERRGHGRIERYPVVARWRTDIYLTIASI
ADFQPFVTSGVAPPPANPLTISQPCIRLDDLDSVGRTGRHLTLFEMMAHH
AFNYPGKEIYWKNETVAYCTELLNELGVKKEDIVYKEEPWAGGGNAGPCL
EAIVGGLEVATLVFMNLEEHPEGDIEIKGARYRKMDNYIVDTGYGLERFV
WASKGTPTVYDAIFPEVVDTIIDNSNVSFNREDERVRRIVAESSKLAGIM
GELRGERLNQLRKSVADTVGVSVEELEGIVVPLEKVYSLADHTRCILFML
GDGLVPSNAGAGYLARLMIRRSLRLAEELELGLDLYDLVEMHKKILGFEF
DVPLSTVQEILELEKERYRTTVSKGTRLVERLVERKKKLEKDDLIELYDS
HGIPVELAVGIAAEKGAEVEMPKDIYAELAKRHSKAEKVQEKKITLQNEY
PATEKLYYDDPTLLEFEAEVIGVEGDFVILNRSAFYPESGGQDNDVGYLI
ANGGKFEVVDVLEADGVVLHVVKGAKPEVGTKVKGVIDSDVRWRHMRHHS
ATHVLLYSLQKVLGNHVWQAGARKEFSKARLDVTHFRRPSEEEIKEIEML
ANREILANKPIKWEWMDRIEAERKFGFRLYQGGVPPGRKIRVVQVGDDVQ
ACGGTHCRSTGEIGMLKILKVESIQDGVIRFEFAAGEAAIEAVEEMERLL
REASSILRVEPAKLPKTVERFFEEWKDQRKEIERLKSVIADLWADILMER
AEEFDSMKVVAEVVDADMQALQKLAERLAEKGAVGCLMAKGEGKVFVVTF
SGQKYDARELLREIGRVAKGSGGGRKDVAQGAVQQLLDREEMLDVIFRFL
SEHEG
Ligand information
>3wqy Chain C (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcucguagcucagcgggagagcgccgccuuugcgaggcggaggccgcg
gguucaaaucccgccgaguccacca
<<<<<<<..<<<<.......>>>>.<<<<<<<...>>>>>>>.....<<<
<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB3wqy The selective tRNA aminoacylation mechanism based on a single G.U pair
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Y95 R128 E189 P190 W191 N359 A360 G361 Y364 T422 R428 R432 R436 E447 Y449 D450 S451 H452 G453 K781 G873 G874 G875 R876 D878 A883
Binding residue
(residue number reindexed from 1)		Y94 R127 E188 P189 W190 N358 A359 G360 Y363 T421 R427 R431 R435 E446 Y448 D449 S450 H451 G452 K780 G872 G873 G874 R875 D877 A882
Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006419 alanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wqy, PDBe:3wqy, PDBj:3wqy
PDBsum3wqy
PubMed24919148
UniProtO28029|SYA_ARCFU Alanine--tRNA ligase (Gene Name=alaS)

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