Structure of PDB 3wpi Chain A Binding Site BS01

Receptor Information

>3wpi Chain A (length=727) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TLPAFLPCELKPHGLVDCNWLFLKSVPRFSCSNITRLSLISNRIHHLHNS
DFVHLSNLRQLNLKWNCPPTGLSSCHMTIEPRTFLAMRTLEELNLSYNGI
TTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCT
GAVKVTPGALLGLSQLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKL
GPEDLAQLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSH
LEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLYESITHTNAFQNLTR
LRKLNLSFNYRRLHLASSFKNLVSLQELNMNGIFFRLLNKYTLRWLADLP
KLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTMDRCKKFTM
DLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLD
LSHNKLDLYHWKSFSELPQLQALDLSYNSQGIGHQFSFVTHLSMLQSLSL
AHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLK
LDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVL
DLAGNQLKALTQGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNL
SHNILKTVDRSWFGPIVMQLTVLDVRSNPLHCACGAAFVDLLLEVQTKVP
GLANGVKCGSPGQLQGRSIFAQDLRLC

Ligand information

>3wpi Chain B (length=9) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cctcgaggg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3wpi Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Resolution	2.246 Å
Binding residue (original residue number in PDB)	K95 Y132 S151 F173 D175 Y179 Y180 K181 S205 K207 Y208 L226 Y229 D250 R256 P262 K338
Binding residue (residue number reindexed from 1)	K64 Y97 S116 F138 D140 Y144 Y145 K146 S170 K172 Y173 L191 Y194 D215 R221 P227 K303

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:3wpi, PDBe:3wpi, PDBj:3wpi
PDBsum	3wpi
PubMed	25686612
UniProt	Q9EQU3\|TLR9_MOUSE Toll-like receptor 9 (Gene Name=Tlr9)

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