Structure of PDB 3wpe Chain A Binding Site BS01

Receptor Information
>3wpe Chain A (length=714) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PAFLPCELQPHGQVDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHLH
DSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEELN
LSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCY
YMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLSY
NHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDT
FSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTTI
FNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSL
TNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISS
CNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPL
TSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSF
VAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLY
LCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNW
SSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVSSNSIGFVIPGF
FVRATRLIELNLSANALKTVDPSWFGAGTLKILDVSANPLHCAAFVDFLL
ERQEAVPVTCGSPG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3wpe Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Resolution2.38 Å
Binding residue
(original residue number in PDB)		W46 K50 S71 R73 H76 W95 S103 P104 M105 F107
Binding residue
(residue number reindexed from 1)		W18 K22 S43 R45 H48 W67 S75 P76 M77 F79
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3wpe, PDBe:3wpe, PDBj:3wpe
PDBsum3wpe
PubMed25686612
UniProtQ5I2M5|TLR9_BOVIN Toll-like receptor 9 (Gene Name=TLR9)

[Back to BioLiP]