Structure of PDB 3wpc Chain A Binding Site BS01

Receptor Information
>3wpc Chain A (length=747) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPPFLPCELQPHGLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHH
LHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE
LNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN
CYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPPSLEYLLL
SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHS
DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKT
KAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFR
SLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI
SGAVEEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSI
SQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQP
FSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSGN
SLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLL
RLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDV
SRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVS
ANPLHCACAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3wpc Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Resolution1.6 Å
Binding residue
(original residue number in PDB)		E616 H641 T642
Binding residue
(residue number reindexed from 1)		E558 H583 T584
Binding affinityPDBbind-CN: Kd=20nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wpc, PDBe:3wpc, PDBj:3wpc
PDBsum3wpc
PubMed25686612
UniProtQ2EEY0|TLR9_HORSE Toll-like receptor 9 (Gene Name=TLR9)

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