Structure of PDB 3wbk Chain A Binding Site BS01

Receptor Information
>3wbk Chain A (length=590) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLRSPICCILGHVDTGKTKLLDKIRQTNAGGITQQIGATYFPIDAIKAKT
KVMAEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHG
LEQQTIESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRA
VQEEFQSRYSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVP
DLLWLLLELTQKRMLSHVEATILEVKVVEGFGTTIDVILSNGYLREGDRI
VLCGMNGPIVTNIRALLTPQPLRELRLKSEYVHHKEVKAALGVKIAANDL
EKAVSGSRLLVVGPEDDEDELMDDVMDDLTGLLDSVDTTGKGVVVQASTL
GSLEALLDFLKDMKIPVMSIGLGPVYKRDVMKASTMLEKAPEYAVMLCFD
VKVDKEAEQYAEQEGIKIFNADVIYHLFDSFTAYQEKLLEERRKDFLDYA
IFPCVLQTLQIINKRGPMIIGVDVLEGTLRVGTPICAVKTDPTTKERQTL
ILGKVISLEINHQPVQEVKKGQTAAGVAVRLEDPSGQQPIWGRHVDENDT
LYSLVSRRSIDTLKDKAFRDQVARSDWLLLKKLKVVFGIE
Ligand information
>3wbk Chain C (length=11) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GEDEELDIDDI
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3wbk X-ray structures of eIF5B and the eIF5B-eIF1A complex: the conformational flexibility of eIF5B is restricted on the ribosome by interaction with eIF1A
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R569 K576 L590 K596
Binding residue
(residue number reindexed from 1)		R557 K564 L578 K584
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:3wbk, PDBe:3wbk, PDBj:3wbk
PDBsum3wbk
PubMed25478828
UniProtP39730|IF2P_YEAST Eukaryotic translation initiation factor 5B (Gene Name=FUN12)

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