Structure of PDB 3wa0 Chain A Binding Site BS01

Receptor Information
>3wa0 Chain A (length=289) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVA
WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVK
KQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRV
INLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFT
IRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI
KPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRK
Ligand information
Receptor-Ligand Complex Structure
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PDB3wa0 Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		R262 N263 I264 S265 Y266 S267 L297 I301 H304
Binding residue
(residue number reindexed from 1)		R239 N240 I241 S242 Y243 S244 L274 I278 H281
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
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Cellular Component
External links
PDB RCSB:3wa0, PDBe:3wa0, PDBj:3wa0
PDBsum3wa0
PubMed24912773
UniProtP46662|MERL_MOUSE Merlin (Gene Name=Nf2)

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