Structure of PDB 3w95 Chain A Binding Site BS01

Receptor Information
>3w95 Chain A (length=149) Species: 103922 (Human enterovirus 71 (strain 7423/MS/87)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMGKFGQQSGAIYVGNFRVVNRHLATHNDWANLVWEDSSRDLLVSSTTA
QGCDTIARCNCQTGVYYCNSRRKHYPVSFSKPSLIYVEASEYYPARYQSH
LMLAQGHSEPGDAGGILRCQHGVVGIVSTGGNGLVGFADVRDLLWLDEE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3w95 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3w95 Crystal Structure of 2A Proteinase from Hand, Foot and Mouth Disease Virus
Resolution1.85 Å
Binding residue
(original residue number in PDB)		C56 C58 C116 H118
Binding residue
(residue number reindexed from 1)		C59 C61 C119 H121
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016032 viral process

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Molecular Function
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Biological Process
External links
PDB RCSB:3w95, PDBe:3w95, PDBj:3w95
PDBsum3w95
PubMed23973886
UniProtQ66479|POLG_HE71M Genome polyprotein

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