Structure of PDB 3w3x Chain A Binding Site BS01

Receptor Information
>3w3x Chain A (length=1021) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEVNRTLLQIVQAFASDNQIRSVAEKALSEEWITENNIEYLLTFLAEQAA
FSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADS
IRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVP
YLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLG
ILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQIIQF
TDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIM
MTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAP
LFQYLQQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLI
NDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRV
QTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSNKLYVQEQALTTI
AFIAEAAKNKFIKYYDTLMPLLLNVLKVNSVLKGKCMECATLIGFAVGKE
KFHEHSQELISILVALQNSDALRSYLEQSWSRICRILGDDFVPLLPIVIP
PLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKV
SAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIP
ILLSCLLAAEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVM
GDNCLSEDQLAAFTKGVSANLTDTYERMQDRDEYNEDFTDEDLLDEINKS
IAAVLKTTNGHYLKNLENIWPMINTFLLEPILVIFALVVIGDLIQYEQTA
SMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDT
LVQIVDSKLEENRSSTENASAAIAKILYAYNSNIPDTYTANWFKTLPTIT
DKEAASFNYQFLSQQSNISAVVDSVIQALNERSLTVISSVKKLLGFLPSS
DAMAIFNRYPADIMEKVHKWF
Ligand information
>3w3x Chain B (length=10) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ANKVTKNKSN
Receptor-Ligand Complex Structure
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PDB3w3x Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Q350 D353 E396 N430 H470 N477 E480 Q512 K556
Binding residue
(residue number reindexed from 1)		Q333 D336 E379 N413 H453 N460 E463 Q495 K535
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008139 nuclear localization sequence binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0007088 regulation of mitotic nuclear division
GO:0015031 protein transport
GO:0060188 regulation of protein desumoylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w3x, PDBe:3w3x, PDBj:3w3x
PDBsum3w3x
PubMed23541588
UniProtP32337|IMB3_YEAST Importin subunit beta-3 (Gene Name=PSE1)

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