Structure of PDB 3w3w Chain A Binding Site BS01

Receptor Information
>3w3w Chain A (length=1028) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPEEVNRTLLQIVQAFASDNQIRSVAEKALSEEWITENNIEYLLTFLAE
QAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSER
ADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILT
TVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWS
KLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQI
IQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVT
LIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYL
AAPLFQYLQQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVI
PLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECT
SRVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSNKLYVQEQAL
TTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNSVLKGKCMECATLIGFAV
GKEKFHEHSQELISILVALQNSDALRSYLEQSWSRICRILGDDFVPLLPI
VIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLD
DKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGAT
LIPILLSCLLAAEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGI
KVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRDEYNEDFTDEDLLDEI
NKSIAAVLKTTNGHYLKNLENIWPMINTFLLEPILVIFALVVIGDLIQYE
QTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPT
LDTLVQIVDGSKLEENRSSTENASAAIAKILYAYNSNIPDTYTANWFKTL
PTITDKEAASFNYQFLSQVCAQSNISAVVDSVIQALNERSLTVISSVKKL
LGFLPSSDAMAIFNRYPADIMEKVHKWF
Ligand information
>3w3w Chain B (length=12) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SAKISKPLHIKT
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3w3w Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D346 H347 R349 Q350 D353 R354 E396 N430 Q434 H470 A473 V476 N477 Q512
Binding residue
(residue number reindexed from 1)		D332 H333 R335 Q336 D339 R340 E382 N416 Q420 H456 A459 V462 N463 Q498
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008139 nuclear localization sequence binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0007088 regulation of mitotic nuclear division
GO:0015031 protein transport
GO:0060188 regulation of protein desumoylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w3w, PDBe:3w3w, PDBj:3w3w
PDBsum3w3w
PubMed23541588
UniProtP32337|IMB3_YEAST Importin subunit beta-3 (Gene Name=PSE1)

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