Structure of PDB 3w1b Chain A Binding Site BS01

Receptor Information
>3w1b Chain A (length=589) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHK
NHVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDAL
KLLNYRTDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDL
IKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHN
VTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQ
SFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIH
NAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCV
FDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVID
ALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILI
VGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELY
DLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVP
SDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGK
Ligand information
Receptor-Ligand Complex Structure
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PDB3w1b Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair
Resolution2.4 Å
Binding residue
(original residue number in PDB)		V14 D18 F42 S45 K48 F49
Binding residue
(residue number reindexed from 1)		V9 D13 F37 S40 K43 F44
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3w1b, PDBe:3w1b, PDBj:3w1b
PDBsum3w1b
PubMed23523427
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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