Structure of PDB 3w0h Chain A Binding Site BS01

Receptor Information

>3w0h Chain A (length=247) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SHDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSML
PHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQ
SFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHE
EEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSH
QLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN

Ligand information

>3w0h Chain C (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NHPMLMNLLKD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3w0h Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	I238 K242 R248 S252 I256 K260 P412 E416
Binding residue (residue number reindexed from 1)	I65 K69 R75 S79 I83 K87 P239 E243

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:3w0h, PDBe:3w0h, PDBj:3w0h
PDBsum	3w0h
PubMed	23462137
UniProt	P13053\|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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