Structure of PDB 3vzg Chain A Binding Site BS01

Receptor Information
>3vzg Chain A (length=138) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSSSYSGEYGSGGGKRFSHSGNQLDGPITALRVRVNTYYIVGLQVRYGKV
WSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKGRYLSFG
KDSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHWDV
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain3vzg Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3vzg Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin
Resolution2.7 Å
Binding residue
(original residue number in PDB)		G35 Y104 G147 S148 L149 D151
Binding residue
(residue number reindexed from 1)		G14 Y83 G126 S127 L128 D130
Annotation score4
Binding affinityPDBbind-CN: -logKd/Ki=1.72,Kd=19mM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042834 peptidoglycan binding
Biological Process
GO:0015031 protein transport
GO:0050830 defense response to Gram-positive bacterium
GO:0052373 suppression of symbiont entry into host
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0031410 cytoplasmic vesicle
GO:0042589 zymogen granule membrane
GO:0062023 collagen-containing extracellular matrix
GO:0070701 mucus layer

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3vzg, PDBe:3vzg, PDBj:3vzg
PDBsum3vzg
PubMed24790092
UniProtO60844|ZG16_HUMAN Zymogen granule membrane protein 16 (Gene Name=ZG16)

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