Structure of PDB 3vul Chain A Binding Site BS01

Receptor Information
>3vul Chain A (length=344) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKK
LSRPFQNQTHAKRAYRELVLMKVVNHKNIIGLLNVFTPQKSLEEFQDVYI
VMELMDANLSQVIQMELDHERMSYLLYQMLVGIKHLHSAGIIHRDLKPSN
IVVKSDATLKILDFGLARRYYRAPEVILGMGYKENVDIWSVGVIMGEMIK
GGVLFPGTDHIDQWNKVIEQLGTPSPEFMKKLQPTVRTYVENRPKYAGYS
FEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPY
INVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3vul Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1
Resolution2.81 Å
Binding residue
(original residue number in PDB)		M121 R127 Y130 S161 D162 W324 E329
Binding residue
(residue number reindexed from 1)		M115 R121 Y124 S155 D156 W304 E309
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D145 K147 N150 D163
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3vul, PDBe:3vul, PDBj:3vul
PDBsum3vul
PubMed23020677
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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