Structure of PDB 3vu1 Chain A Binding Site BS01

Receptor Information

>3vu1 Chain A (length=488) Species: 70601 (Pyrococcus horikoshii OT3)

EIEVTGWEQALKWLRSNTSKYATATSWWDYGYWIESSLLGNRRRDRDHIL
ALFLARDGNISEVDFESWELNYFIIYLNDWAKFNAISYLGGAITRKEYNG
DENGRGRVTTILLTQAAGNVYVNPYARIVIKVIQQNKTRRIAVNIGQLEC
SPILSVAFPGNIKIKGSGRCSDGSPFPYVVYLTPSLGVLAYYKVATSNFV
KLAFGIPTSSYSEFAEKLFSNFIPVYQYGSVIVYEFRPFAIYKIEDFING
TWREVGKLSPGKHTLRLYISAFGRDIKNATLYVYALNGTKIIKRIKVGEI
KYMNHLEEYPIIVNVTLPTAQKYRFILAQKGPVGVLTGPVRVNGKITNPA
YIMREGESGRLELKVGVDKEYTADLYLRATFIYLVRKGGKSNEDYDASFE
PHMDTFFITKLKEGIKLRPGENEIVVNAEMPKNAISSYKEKLEKEHGDKL
IIRGIRVEPVFIVEKEYTMIEVSASAPHHHHHHHHHHH

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 3vu1 Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3vu1 Crystallographic and NMR Evidence for Flexibility in Oligosaccharyltransferases and Its Catalytic Significance
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): E556 A765 H799 E802
• Binding residue (residue number reindexed from 1): E62 A271 H305 E308
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 2.4.99.21: dolichyl-phosphooligosaccharide-protein glycotransferase.

Gene Ontology

Molecular Function

• GO:0004576 oligosaccharyl transferase activity

Biological Process

• GO:0006486 protein glycosylation

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3vu1, PDBe:3vu1, PDBj:3vu1
• PDBsum: 3vu1
• PubMed: 23177926
• UniProt: O74088|AGLB1_PYRHO Dolichyl-phosphooligosaccharide-protein glycotransferase 1 (Gene Name=aglB1)