Structure of PDB 3vru Chain A Binding Site BS01

Receptor Information

>3vru Chain A (length=238) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRPLSMLPHLADLVSY
SIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSW
DCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAI
CIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQK
LADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN

Ligand information

>3vru Chain C (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NHPMLMNLLK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3vru Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands
Resolution	2.0 Å
Binding residue (original residue number in PDB)	I238 K242 S252 Q255 I256 K260 P412 E416
Binding residue (residue number reindexed from 1)	I56 K60 S70 Q73 I74 K78 P230 E234

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:3vru, PDBe:3vru, PDBj:3vru
PDBsum	3vru
PubMed	22512505
UniProt	P13053\|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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