Structure of PDB 3vrh Chain A Binding Site BS01

Receptor Information
>3vrh Chain A (length=298) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKCKFCSREAYIKIHYPKMYLCEEHFKEYFERKVSRTIERYKLLTKDERI
LVAVSGGKDSAVTAYVLKKLGYNIECLHINLGISGYSEKSEEYAKKQCKL
IGAPLHIVRIKEILGYGIGEVKTRRPPCSYCGLTKRYIMNKFAYDNGFDA
IATGHNLDDEASFLLNNILHWNTEYLAKGGPILPQQGKFIKKVKPLYEVT
EREVVAYALAVGLEYIVEECPYTTLDMKGVLNELEEKRPGTKFNFVRGYL
KKKKLFEPKECKICRMPSSGDICAFCKFWGLKKEINFKVSSTDEEPFG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3vrh Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3vrh Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		C3 C22 H25
Binding residue
(residue number reindexed from 1)		C3 C22 H25
Annotation score1
Enzymatic activity
Enzyme Commision number 2.8.1.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002143 tRNA wobble position uridine thiolation
GO:0008033 tRNA processing
GO:0034227 tRNA thio-modification
Cellular Component
GO:0002144 cytosolic tRNA wobble base thiouridylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3vrh, PDBe:3vrh, PDBj:3vrh
PDBsum3vrh
PubMed23444054
UniProtO58038|TTUA_PYRHO tRNA-5-methyluridine(54) 2-sulfurtransferase (Gene Name=ttuA)

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