Structure of PDB 3vb4 Chain A Binding Site BS01

Receptor Information
>3vb4 Chain A (length=301) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDML
NPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
S
Ligand information
Receptor-Ligand Complex Structure
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PDB3vb4 Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
Resolution2.2 Å
Binding residue
(original residue number in PDB)		M49 F140 C145 H163 H164 M165 E166 P168 Q189 T190 A191
Binding residue
(residue number reindexed from 1)		M49 F140 C145 H163 H164 M165 E166 P168 Q189 T190 A191
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G143 C145
Catalytic site (residue number reindexed from 1) H41 G143 C145
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:3vb4, PDBe:3vb4, PDBj:3vb4
PDBsum3vb4
PubMed23202846
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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