Structure of PDB 3v1r Chain A Binding Site BS01

Receptor Information
>3v1r Chain A (length=165) Species: 356663 (Xenotropic MuLV-related virus VP35) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGTRPDLTDQPIPDADYTWYTDGSSFLQEGQRRAGAAVTTETEVIWARAL
PAGTSAQRAELIALTQALKMAEGKKLNVYTDSRYAFATAHVHGEIYRRRG
LLTSEGREIKNKNEILALLKALFLPKRLSIIHCPGHQKGNSAEARGNRMA
DQAAREAAMKAVLET
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3v1r Chain A Residue 673 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3v1r Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D524 E562 D583
Binding residue
(residue number reindexed from 1)		D22 E60 D81
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3v1r, PDBe:3v1r, PDBj:3v1r
PDBsum3v1r
PubMed22366278
UniProtQ2F7J3|POL_XMRV3 Gag-Pol polyprotein (Gene Name=gag-pol)

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