Structure of PDB 3v11 Chain A Binding Site BS01

Receptor Information

>3v11 Chain A (length=404) Species: 273057 (Saccharolobus solfataricus P2)

QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNI
GVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLS
GAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSK
EEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPY
RDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVL
PGLRVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNL
LGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSV
GSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWG
LVEI

Ligand information

>3v11 Chain C (length=17) Species: 273057 (Saccharolobus solfataricus P2)

SEKEYVEMLDRLYSKLP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3v11 Structure of the ternary initiation complex aIF2-GDPNP-methionylated initiator tRNA.
• Resolution: 5.0 Å
• Binding residue (original residue number in PDB): P65 V151 K156 A159 Y163 R164 K167 I181 P182 V183 I189 N190 D192 S193
• Binding residue (residue number reindexed from 1): P59 V145 K150 A153 Y157 R158 K161 I175 P176 V177 I183 N184 D186 S187

Enzymatic activity

• Catalytic site (original residue number in PDB): D19 K22 T23 T46 H97
• Catalytic site (residue number reindexed from 1): D13 K16 T17 T40 H91
• Enzyme Commision number: 3.6.5.3: protein-synthesizing GTPase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003743 translation initiation factor activity
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001731 formation of translation preinitiation complex
• GO:0006412 translation
• GO:0006413 translational initiation
• GO:0006414 translational elongation

External links

• PDB: RCSB:3v11, PDBe:3v11, PDBj:3v11
• PDBsum: 3v11
• PubMed: 22447243
• UniProt: Q980A5|IF2G_SACS2 Translation initiation factor 2 subunit gamma (Gene Name=eif2g)